Progress in identifying virulence determinants of the 1918 H1N1 and the Southeast Asian H5N1 influenza A viruses
Identifieur interne : 001231 ( Main/Exploration ); précédent : 001230; suivant : 001232Progress in identifying virulence determinants of the 1918 H1N1 and the Southeast Asian H5N1 influenza A viruses
Auteurs : Christopher F. Basler ; Patricia V. AguilarSource :
- Antiviral research [ 0166-3542 ] ; 2008.
Abstract
The 1918 pandemic H1N1 influenza virus and the recently emerged Southeast Asian H5N1 avian influenza virus are unique among influenza A virus isolates in their high virulence for humans and their lethality for a variety of animal species without prior adaptation. Reverse genetic studies have implicated several viral genes as virulence determinants. For both the 1918 and H5N1 viruses, the hemagglutinin and the polymerase complex contribute to high virulence. Non-structural proteins NS1 and PB1-F2, which block host antiviral responses, also influence pathogenesis. Additionally, recent studies correlate high levels of viral replication and induction of strong proinflammatory responses with the high virulence of these viruses. Defining how individual viral proteins promote enhanced replication, inflammation and severe disease will provide insight into the pathogenesis of severe influenza virus infections and suggest novel therapeutic approaches.
Url:
DOI: 10.1016/j.antiviral.2008.04.006
PubMed: 18547656
PubMed Central: 2547130
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000555
- to stream Pmc, to step Curation: 000555
- to stream Pmc, to step Checkpoint: 000B03
- to stream Ncbi, to step Merge: 000294
- to stream Ncbi, to step Curation: 000294
- to stream Ncbi, to step Checkpoint: 000294
- to stream Main, to step Merge: 001242
- to stream Main, to step Curation: 001231
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Progress in identifying virulence determinants of the 1918 H1N1 and the Southeast Asian H5N1 influenza A viruses</title>
<author><name sortKey="Basler, Christopher F" sort="Basler, Christopher F" uniqKey="Basler C" first="Christopher F." last="Basler">Christopher F. Basler</name>
</author>
<author><name sortKey="Aguilar, Patricia V" sort="Aguilar, Patricia V" uniqKey="Aguilar P" first="Patricia V." last="Aguilar">Patricia V. Aguilar</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">18547656</idno>
<idno type="pmc">2547130</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2547130</idno>
<idno type="RBID">PMC:2547130</idno>
<idno type="doi">10.1016/j.antiviral.2008.04.006</idno>
<date when="2008">2008</date>
<idno type="wicri:Area/Pmc/Corpus">000555</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000555</idno>
<idno type="wicri:Area/Pmc/Curation">000555</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000555</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000B03</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B03</idno>
<idno type="wicri:Area/Ncbi/Merge">000294</idno>
<idno type="wicri:Area/Ncbi/Curation">000294</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000294</idno>
<idno type="wicri:doubleKey">0166-3542:2008:Basler C:progress:in:identifying</idno>
<idno type="wicri:Area/Main/Merge">001242</idno>
<idno type="wicri:Area/Main/Curation">001231</idno>
<idno type="wicri:Area/Main/Exploration">001231</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Progress in identifying virulence determinants of the 1918 H1N1 and the Southeast Asian H5N1 influenza A viruses</title>
<author><name sortKey="Basler, Christopher F" sort="Basler, Christopher F" uniqKey="Basler C" first="Christopher F." last="Basler">Christopher F. Basler</name>
</author>
<author><name sortKey="Aguilar, Patricia V" sort="Aguilar, Patricia V" uniqKey="Aguilar P" first="Patricia V." last="Aguilar">Patricia V. Aguilar</name>
</author>
</analytic>
<series><title level="j">Antiviral research</title>
<idno type="ISSN">0166-3542</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">The 1918 pandemic H1N1 influenza virus and the recently emerged Southeast Asian H5N1 avian influenza virus are unique among influenza A virus isolates in their high virulence for humans and their lethality for a variety of animal species without prior adaptation. Reverse genetic studies have implicated several viral genes as virulence determinants. For both the 1918 and H5N1 viruses, the hemagglutinin and the polymerase complex contribute to high virulence. Non-structural proteins NS1 and PB1-F2, which block host antiviral responses, also influence pathogenesis. Additionally, recent studies correlate high levels of viral replication and induction of strong proinflammatory responses with the high virulence of these viruses. Defining how individual viral proteins promote enhanced replication, inflammation and severe disease will provide insight into the pathogenesis of severe influenza virus infections and suggest novel therapeutic approaches.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Aguilar, Patricia V" sort="Aguilar, Patricia V" uniqKey="Aguilar P" first="Patricia V." last="Aguilar">Patricia V. Aguilar</name>
<name sortKey="Basler, Christopher F" sort="Basler, Christopher F" uniqKey="Basler C" first="Christopher F." last="Basler">Christopher F. Basler</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001231 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001231 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:2547130 |texte= Progress in identifying virulence determinants of the 1918 H1N1 and the Southeast Asian H5N1 influenza A viruses }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:18547656" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a H2N2V1
This area was generated with Dilib version V0.6.33. |